These Terms and Conditions of Use (the "Terms of Use") apply to the BCN Bio-HF Calculator web, the "Site". The Site is the property of FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL. By using the site, you agree to these terms of use; if you do not agree, do not use the site.

FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL reserves the right, at its sole discretion, to change, modify, add or remove portions of these Terms of Use, at any time. It is your responsibility to check these Terms of Use periodically for changes. Your continued use of the Site following the posting of changes will mean that you accept and agree to the changes.

Content and Use of the Site

As a condition of using the BCN Bio-HF Calculator you accept that the information contained in the BCN Bio-HF Calculator is intended as a supplement to, and not a substitute for, your knowledge, expertise, skill and professional judgment. FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL makes no representations or warranty on the accuracy, validity, completeness or availability of information or results obtained from the BCN Bio-HF Calculator. Information provided by the BCN Bio-HF Calculator should not be construed to indicate that any particular outcome, treatment or treatment combination is safe, appropriate or effective in any given patient.

All text, graphics, user interfaces, visual interfaces, photographs, trademarks, logos, sounds, music, artwork and computer code (collectively, "Content"), including but not limited to the design, structure, selection, coordination, _expression, "look and feel" and arrangement of such Content, contained on the Site is owned by FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL, and is protected by copyright.

Except as expressly provided in these Terms of Use, no part of the Site and no Content may be copied, reproduced, republished, uploaded, posted, publicly displayed, encoded, translated, transmitted or distributed in any way (including "mirroring") to any other computer, server, Web site or other medium for publication or distribution or for any commercial enterprise, without FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL express prior written consent.

You may use information on the BCN Bio-HF Calculator (such as printouts of a screenshot), provided that you (1) not remove any proprietary notice language in all copies of such documents, (2) use such information only for your personal, non-commercial informational purpose and do not copy or post such information on any networked computer or broadcast it in any media, (3) make no modifications to any such information, and (4) not make any additional representations or warranties relating to such documents.

You may not use any "deep-link", "page-scrape", "robot", "spider" or other automatic device, program, algorithm or methodology, or any similar or equivalent manual process, to access, acquire, copy or monitor any portion of the Site or any Content, or in any way reproduce or circumvent the navigational structure or presentation of the Site or any Content, to obtain or attempt to obtain any materials, documents or information through any means not purposely made available through the Site.

Disclaimers

FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL DOES NOT PROMISE THAT THE SITE OR ANY CONTENT, OR FEATURE OF THE SITE WILL BE ERROR-FREE OR UNINTERRUPTED, OR THAT ANY DEFECTS WILL BE CORRECTED, OR THAT YOUR USE OF THE SITE WILL PROVIDE SPECIFIC RESULTS. THE SITE AND ITS CONTENT ARE DELIVERED ON AN “AS-IS” AND “AS-AVAILABLE” BASIS. ALL INFORMATION PROVIDED ON THE SITE IS SUBJECT TO CHANGE WITHOUT NOTICE.

FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL DISCLAIMS ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY WARRANTIES OF ACCURACY, NON-INFRINGEMENT, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL DISCLAIMS ANY AND ALL LIABILITY FOR THE ACTS, OMISSIONS AND CONDUCT OF ANY THIRD PARTIES IN CONNECTION WITH OR RELATED TO YOUR USE OF THE SITE. YOU ASSUME TOTAL RESPONSIBILITY FOR YOUR USE OF THE SITE AND ANY LINKED SITES. YOUR SOLE REMEDY AGAINST FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL FOR DISSATISFACTION WITH THE SITE OR ANY CONTENT IS TO STOP USING THE SITE OR ANY SUCH CONTENT. THIS LIMITATION OF RELIEF IS A PART OF THE BARGAIN BETWEEN THE PARTIES.

The above disclaimer applies to any damages, liability or injuries caused by any failure of performance, error, omission, interruption, deletion, defect, delay in operation or transmission, computer virus, communication line failure, theft or destruction of or unauthorized access to, alteration of, or use, whether for breach of contract, tort, negligence or any other cause of action.

FUNDACIÓ D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL reserves the right to do any of the following, at any time, without notice: (1) to modify, suspend or terminate operation of or access to the Site, or any portion of the Site, for any reason; (2) to modify or change the Site, or any portion of the Site, and any applicable policies or terms; and (3) to interrupt the operation of the Site, or any portion of the Site, as necessary to perform routine or non-routine maintenance, error correction, or other changes.

Miscellaneous

Predictions and the performance of the models were calculated at 1, 2 and 3 years of follow-up. The calculator was designed to run with availability of none, one, two or the three chosen biomarkers.

Age, sex and NYHA functional class are mandatory fields. Whenever LVEF, sodium, haemoglobin or eGFR are missing median values will be applied. Whenever any given value is out of range the 99th percentile will be applied. Median values and calculation limits (99th percentiles) are displayed in Table 1. Graphic display of survival curves were developed using monthly survival probabilities.

The superior limit for life expectancy was set to mean life expectancy in Catalonian population in 2010(www.idescat.cat) or to >20 years if higher, as current follow-up does not allow to predict so long-term accurately (Table 2).

Table 1: Limits (99th percentile) and median values in the BCN Bio-HF calculator

	Lower limit	Upper limit	Median
Age, years	35	88	70.3
LVEF, %	10	71	34
Na, mmol/L	130	147	139
eGFR, ml/min/1.73m2	6	110	42.4
Hemoglobin, g/dL	8.7	17.1	12.9
NTproBNP	21	34800	1361.5
hs-cTnT	3	265	22.6
ST2	18	157	38.1
HF duration	0.5	232	27
No. of HF hospitalizations	0	4	0

eGFR= estimated glomerular filtration rate; hs-cTnT, high-sensitivity circulating troponin T; LVEF= left ventricular ejection fraction; NT-proBNP= N-terminal pro-brain natriuretic peptide; ST2= high-sensitivity soluble ST2.

Table 2: Limits of life expectancy in the BCN Bio-HF calculator according to age and sex

Age (years)	Men	Women
≤63	>20	>20
64	19,3	>20
65	18,5	>20
66	17,8	>20
67	17,0	>20
68	16,2	20,0
69	15,5	19,0
70	14,7	18,2
71	14,0	17,3
72	13,4	16,5
73	12,7	15,7
74	12,1	14,9
75	11,4	14,1
76	10,8	13,3
77	10,1	12,5
78	9,5	11,7
79	8,8	10,9
80	8,3	10,1
81	7,7	9,5
82	7,3	9,0
83	6,9	8,4
84	6,4	7,8
85	6,0	7,3
86	5,5	6,7
87	5,1	6,2
88	4,7	5,6